When subjected to ligature of the coronary artery to cause myocardial infarction (MI), despite similar infarct size and left ventricular dysfunction post-MI, those on the safflower oil diet had decreased 5-, 12- and 15-lipoxygenases in the infarcted left ventricle, lower levels of pro-resolving mediators and increased expression of TNF-α and IL-1β compared to mice receiving the chow diet43. This evidence concerns the gene TNF and myocardial infarction.