Next, we explored whether ImP levels were associated with inflammatory serum markers in the population and observed that serum ImP levels were positively correlated with serum markers of inflammation [total leucocytes count, high sensitive C-reactive protein (hs-CRP), interferon gamma-induced protein 10 (IP-10)] after correction for known traditional risk factors (Model 1: age, gender, BMI, ethnicity), for kidney function (Model 2: Model 1 + creatinine clearance), and for the presence of type 2 diabetes (Model 3: Model 2 + diabetes status) (Fig. 2d and Supplementary Table 5). This evidence concerns the gene CRP and type 2 diabetes mellitus.