Based on these data indicating that the effects of FANA-CD39-AS oligonucleotides on Jurkat cells and healthy control Treg and Th17 cells were mainly evident at 72 h, further experiments were conducted to test the effects of FANA-CD39-AS addition in Treg and Th17 cells obtained from a larger number of healthy controls and Crohn’s disease patients (Fig. 3d, e). Here, ENTPD1 is linked to Crohn disease.