We initially observed that clathrin-mediated pathways such as DNM1, DNM2, and SH3GL2 (endophilin) were downregulated in microdissected glomeruli in this CKD cohort, which included glomerular diseases such as membranous nephropathy, lupus nephritis (LN), and diabetic kidney disease (Supplemental Figure 1, A–C; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.142740DS1). This evidence concerns the gene SH3GL2 and glomerular disorder.