GAK and glomerulosclerosis: Compared with Gak-KO mice, we observed a striking reduction in albuminuria (Figure 8A), kidney failure (Figure 8B), glomerulosclerosis (Figure 8C and quantified in Figure 8E), tubulointerstitial injury (Figure 8D and quantified in Figure 8F), and foot process effacement in Gak/Gadd45b-DKO mice (Figure 8H and quantified in Figure 8I).