ERRFI1 and cardiac hypertrophy: Genes with significantly increased expression after therapy included the metallothioneins MT1X and MT2A, a divalent cation transporter protein (SLC11A1); ERRFI1, G protein receptor genes that have been implicated in preventing cardiac hypertrophy (RGS2, RGS1); and GADD45B, a gene found to have increased expression with stress-induced growth arrest.