Genes significantly downregulated with pazopanib therapy included ENPP2 (autotaxin), which has been implicated in angiogenesis and tumor cell motility; the cadherin FAT3; and the kidney-enriched cytochrome monooxygenase CYP4A11. To evaluate whether gene expression patterns were consistent with activation of specific biological processes, we performed gene set enrichment analysis (GSEA) (20). The gene discussed is CYP4A11; the disease is neoplasm.