ENPP2 and neoplasm: Genes significantly downregulated with pazopanib therapy included ENPP2 (autotaxin), which has been implicated in angiogenesis and tumor cell motility; the cadherin FAT3; and the kidney-enriched cytochrome monooxygenase CYP4A11. To evaluate whether gene expression patterns were consistent with activation of specific biological processes, we performed gene set enrichment analysis (GSEA) (20).