Scavenger receptor type B-1 (SCARB1) is a high-affinity receptor for cholesterol-rich high-density lipoproteins (HDLs), which has been implicated as a target in human cancers based upon its role in cancer cell cholesterol uptake (19, 20, 21, 22, 23, 24, 25, 26, 27) and in membrane-anchored second messenger signaling pathways (23, 28, 29, 30, 31), among other factors (32, 33, 34, 35). The gene discussed is SCARB1; the disease is cancer.