Here we investigated the relationship between the inflammasome components and IRGM, with regard to Golgi structure during viral infection (i.e., HCV and Zika virus [ZIKV]) or chemical stimuli culminating in the assignment of a newly defined relationship between components of the NLRP3 inflammasome and host intracellular compartments in response to HCV infection or some stimuli or stress. Here, NLRP3 is linked to viral infectious disease.