ClinGen gene-specific ACMG-based specifications in cancer susceptibility are currently finalised for PTEN, TP53 and CDH1.6–8 CanVIG-UK is a national sub-specialty multi-disciplinary genomic network through which we have attained consensus and improved consistency within the UK clinical-laboratory community around application of the 2015 ACMG framework for these and other CSGs. The gene discussed is PTEN; the disease is cancer.