Moreover, ADAM22 expression correlated with known brain metastatic associated [28, 29] in both primary (MOCS1, n = 21, p < 0.05) and metastatic tumours (MOCS1, COL13A1, TLR4, HBEGF and PELI2, n = 21, p < 0.05). The gene discussed is TLR4; the disease is metastatic neoplasm.