Moreover, ADAM22 expression correlated with known brain metastatic associated [28, 29] in both primary (MOCS1, n = 21, p < 0.05) and metastatic tumours (MOCS1, COL13A1, TLR4, HBEGF and PELI2, n = 21, p < 0.05). This evidence concerns the gene ADAM22 and metastatic neoplasm.