GBM-MG co-culture downregulated multiple immune response-related pathways in GBM cells including nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs), tumor necrosis factor (TNF) signaling, nuclear factor kappa-beta (NF-κB) signaling, toll-like receptor signaling (TLRs), and mitogen-activated protein kinase (MAPK) signaling. Here, WNK2 is linked to glioblastoma.