Besides, AST elevated the expression of IL-4 in the hippocampus and prefrontal cortex in a dose-dependent manner when compared with that in LUCCAO group, and reached the highest at AST 200 mg/kg (P < 0.0001) (Fig. 5c, d) According to the above results, it was implied that AST could regulate the expression of inflammatory cytokines in VD mice. This evidence concerns the gene IL4 and sexually transmitted disease.