While a portion of these may be shared mutations may be germline variants, we identified a GATA3 splice-site deletion in regions 1A and 1B previously observed in DCIS studies, disrupting a canonical splice site and for which the resulting transcript has been shown to lead to an abnormally high number of neoantigens [51, 52]. The gene discussed is GATA3; the disease is ductal breast carcinoma in situ.