Results showed many enriched gene-sets in periodontitis were associated with immune processes or regulations (Fig. 6b–e) such as CD4 T CELL VS B CELL DOWN in immunologic signature, IL6 JAK STAT6 SIGNALING in hallmark, POSITIVE REGULATION OF B CELL DIFFERENTIATION in GO and T HEPLER PATHWAY in the canonical pathway. This evidence concerns the gene CD4 and periodontitis.