ABCC2 and Wilson disease: Conversely, the lack of PLC development in the three siblings with ABCC2 c.3972C > T SNP alone or in association with Wilson disease, but not exposed to these carcinogens and other known risk factors for PLC, suggest that these two genetic conditions may be not sufficient for PLC development, but that co-occurrence of further host/exogenous risk factors are likely needed to drive this process.