PTEN and renal cell carcinoma: In fact, our analysis revealed a specific nivolumab-mediated induction of the miR-22 expression, which is coherent with recent studies showing that this miRNA is downregulated both in serum and tissues of ccRCC patients and, therefore, it can act as tumor suppressor, since its loss of expression could contribute to the RCC development via the PTEN-mediated induction of cell proliferation, migration, and invasion [23].