LUM and granular cell tumor: In addition to these, several essential ECM proteins, including lumican, vintronectin, collagen alpha III, etc., also reduced their expressions in the GCT-untreated/control group were shown in Figure 4C. Furthermore, the molecular chaperon heat shock protein 70 was down-regulated in the untreated/control group showed increased expressions after the cryoablation treatment of GCT.