Interestingly, overexpression of Pim-1 either in c-kit+ bone-marrow derived cells (BMCs) [11], c-kit+ mCPCs [12], or c-kit+ hCPCs isolated from patients with heart failure [13,14] has been shown to enhance cardiac repair in both rodent and porcine models of myocardial infarct. This evidence concerns the gene KIT and myocardial infarction.