NOTCH1 and obesity due to melanocortin 4 receptor deficiency: Moreover, the MiR-30 family is highly conserved [176,177,178] and may play a role in modulating the polarization of macrophages in visceral AT through regulation of Delta-like protein 4 (DLL4; a Notch1 ligand that contributes to metabolic disease and macrophage inflammation), with downregulation of several miRNAs of the MiR-30 family (MiR-30a-5p, MiR-30c-5p, and MiR-30e-5p) in adipose tissue macrophages in obesity [153].