This adipogenesis dysregulation can be attributed to the pro-inflammatory environment of WAT in obesity, where pro-inflammatory cytokines (e.g., TNFA) can exert anti-adipogenic effects on adipocytes through downregulation of PPARG, C/EBPA and FABP4 expression [224,225,226]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.