MAPT and Alzheimer disease: In particular, in 2011, Braak et al. [44] analyzed hundreds of brains of subjects showing different degrees of AD pathology and showed that the progressive accumulation of p-Tau in LC precedes by years the occurrence of neurofibrillary tangles (NFT) deposits in the entorhinal cortex (which was classically considered, up to that study, as the first cortical site involved by Tau pathology in AD).