HMGB1 and cardiovascular disorder: Furthermore, chronic and abnormal activation of some inducible enzymes, including NADPH oxidase (NOX), inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, high-mobility group box 1 (HMGB1), superoxide dismutase (SOD), and glutathione peroxidase (GPx), have been shown to play vital roles in the development of some inflammatory diseases such as oncogenesis and cardiovascular disease [24,27].