Furthermore, the CRC survivors in the highest category of the American Cancer Society recommendations (ACS score) and the WCRF/AICR score had a 30% (RR/HR = 0.70, 95% CI = 0.56–0.86) and 21% (RR/HR = 0.79, 95% CI = 0.65–0.98) lower risk of all-cause mortality compared with those in the lowest category, whereas the subjects in the highest category of glycemic load and insulin index had a 74% (RR/HR = 1.74, 95% CI = 1.20–2.51) and 51% (RR/HR = 1.51, 95% CI = 1.07–2.12) higher risk of all-cause mortality, respectively. This evidence concerns the gene INS and cancer.