INS and colorectal carcinoma: Interestingly, in a subgroup analysis of the insulin load or index, which were defined as risk factors for both all-cause mortality and CRC-specific mortality in this study, a lower risk of CRC-specific mortality with coffee intake was observed only in the lower category of insulin load (HR = 0.83, 95% CI = 0.70–0.98) despite the null association for the dietary insulin index [27].