ONCOS-102 is a highly modified oncolytic Ad vector including a chimeric 5/3 fiber-knob region for increased infectivity, a 24-bp deletion in the E1A region for selective replication in cells with dysfunctional Rb pathway, and the transgene insertion of GM-CSF to improve immune cell infiltration at the tumor site [65,66]. The gene discussed is RB1; the disease is neoplasm.