Moreover, in an attempt to reveal the underlying mechanisms that mediate the aggressive phenotypes of DNA-PKcs, the same group performed unbiased investigations in multiple tumor models, which revealed that DNA-PKcs is pleiotropic, involved in the regulation of various biological processes beyond DNA repair, such as epithelial–mesenchymal transition (EMT), immune response, and metabolic processes [20,30]. This evidence concerns the gene PRKDC and neoplasm.