By integrating the mutational landscape of 1319 cancer-associated genes with sensitivity data of DNA-PKcs inhibition across 67 cell lines [71], Dietlein and colleagues identified a considerable number of genes involved in homologous recombination-mediated DNA repair, including BRCA1 (Breast And Ovarian Cancer Susceptibility Protein 1), BRCA2 (Breast And Ovarian Cancer Susceptibility Protein 2), ATM (Ataxia Telangiectasia Mutated), PAXIP1 (paired box paired box 1), and RAD50 (DNA repair protein RAD50), whose mutations led to non-oncogene addiction to DNA-PKcs. This evidence concerns the gene PRKDC and cancer.