Further elucidation of these questions with genome-wide genetic and/or pharmacological studies (e.g., DNA-PKcs inhibitor-based shRNA [short hairpin RNA]/CRISPR [clustered regularly interspaced short palindromic repeats] screens, integrated pharmaco-transcriptomic analyses) will deepen our knowledge about the molecular mechanisms determining the therapeutic responses to DNA-PKcs inhibitors [89,90], and will contribute greatly to the future design of precision treatment of cancer patients with DNA-PKcs-targeted therapy. This evidence concerns the gene PRKDC and cancer.