In the public The Cancer Genome Atlas (TCGA) database, genetic alterations of PRKDC (Protein Kinase, DNA-Activated, Catalytic Subunit; encoding DNA-PKcs), e.g., point mutations and copy number amplifications, are common in a variety of cancer types, particularly in uterine corpus endometrial carcinoma (UCEC), uterine carcinosarcoma (UCS), skin cutaneous melanoma (SKCM), stomach adenocarcinoma (STAD), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), and colorectal adenocarcinoma (COADRE) (frequency > 10%) (Figure 1A). The gene discussed is PRKDC; the disease is cutaneous melanoma.