We mined drug sensitivity data of NU7441, a selective DNA-PKcs inhibitor [23], in GDSC (Genomics of Drug Sensitivity in Cancer, https://www.cancerrxgene.org/) and showed that cancer cell lines from soft tissue and thyroid are particularly sensitive to NU7441, whereas cancer cell lines with other lineages display highly heterogeneous responses to NU7441 (Figure 5A,B). Here, PRKDC is linked to cancer.