Guilardi et al. have demonstrated that trypsin-3 (also named pretrypsinogen III), encoded by Try3 in the rat and PRSS3 in humans, is overexpressed under the combined action of VEGF-A (Vascular endothelial growth factor A) and FGF-2 (Fibroblast growth factor 2) in endothelial cells, thereby boosting their migration and tumor angiogenesis [44]. This evidence concerns the gene PRSS3 and neoplasm.