In addition, our previous data showing the interaction between 37/67kDa LR and APP in mouse neuronal cells [10], together with the finding of regulation of APP maturation through receptor inhibition, prompted us to analyze the role of 37/67kDa LR in AD by challenging the specific receptor inhibitor NSC47924 (previously found active on prion protein trafficking) [22], with cells derived from fAD patients. The gene discussed is APP; the disease is familial Alzheimer disease.