In this context, the already acknowledged role of 37/67kDa laminin receptor (LR) in the internalization and cytotoxicity of Aβ [16,17], together with our recent finding of its interaction with APP and its involvement in APP localization and maturation in neuronal cells [10], prompted us to analyze the effects of a specific inhibitor of 37/67kDa LR on the localization and processing of APP, as well as on Aβ generation, in fibroblast cell lines from familial AD patients compared with healthy unaffected ones. The gene discussed is APP; the disease is Alzheimer disease.