Although we found that miR-483-3p is expressed higher in cells susceptible to SARS-CoV-2 infection, its upregulation (4.46-fold) along with the upregulation of miR-181c-5p and let-7d-5p after infection in Calu-3 cells may represent compensatory responses of host cells to inhibit SARS-CoV-2 entry by targeting ACE2 and TMPRSS2 mRNA. The gene discussed is ACE2; the disease is infection.