BRAF and melanoma: Although these are among the most recurrent mutations in melanoma and are associated with carcinogenesis, neither is a canonical UV signature mutation: NRAS Q61R is caused by a T>C mutation, while BRAF V600E is caused by a T>A mutation in a non-Dipyr context (Hodis et al., 2012; Pandiani et al., 2017; Sample and He, 2018).