Consistent with the upregulation of YAP signatures in TD compared with A549 (Fig. 1E), the nuclear localization of YAP (Fig. 1F and Fig. S1D), a robust indicator of YAP activation, and high reporter activity at low cell density, which inhibits Hippo signaling activity (Fig. 1G), were observed in TD cells. Here, YAP1 is linked to thanatophoric dysplasia.