In this study, we used a doxorubicin‐resistant isogenic pair of lung cancer cell lines to demonstrate that YAP activation in mesenchymal‐type lung cancer cells (Fig. 1) induced AXL expression upon doxorubicin treatment (Fig. 2) and contributed to doxorubicin resistance (Figs 4 and 5). This evidence concerns the gene YAP1 and lung cancer.