TGFB1 and familial pancreatic carcinoma: For premetastatic niche formation in distant organs, Costa‐Silva et al. showed not only the above‐mentioned central role of sEVs from pancreatic cancer cells, they also point out a role of TGF‐β signaling activation leading to ECM remodeling, fibronectin induction, and the influx of bone marrow‐derived macrophages to the liver, which are favorable for consecutive liver metastasis [52].