A recent in‐depth analysis of in vitro‐ and in vivo‐released EV subpopulations from glioblastoma cells expressing the mutant EGFR U87EGFRvIII showed that that small and large EVs contained tumor‐specific EGFRvIII mRNA and proteins and that the EGFR protein content (wild‐type and mutant) was significantly higher in the latter [115]. Here, EGFR is linked to glioblastoma.