Quantification of serum EV‐TGF‐β1 content by ELISA showed a significant increase in pancreatic cancer patients, while coculture experiments of EVs with natural killer cells demonstrated a significant downregulation of various immunomodulatory proteins (such as NKG2D, CD107a, TNF‐α, and INF‐γ) [105]. This evidence concerns the gene TGFB1 and familial pancreatic carcinoma.