However, in pancreatic ductal adenocarcinoma Yin et al. [101] reported the relevance of M2 macrophage‐derived exosomal miR‐501‐3p to inhibit the tumor suppressor TGFBR3 and therefore facilitating tumor development by TGF‐β signaling leaving question of context dependencies not only of EV‐mediated signaling but also of TGF‐β signaling per se. This evidence concerns the gene TGFB1 and neoplasm.