STAT3 and neoplasm: Fig 3E depicts representative serial tumor volumes derived from 3D reconstructed ultrasound images. Aligned with this finding, UTMC-mediated STAT3 decoy delivery increased tumor doubling time compared to that of untreated control (4.2±0.4 vs 3.5±0.4 days, p<0.05) and mutant control decoy (3.7±0.4, p = 0.056), resulting in reduced mortality of the STAT3 decoy treated mice. Kaplan-Meier curves (Fig 4) indicated that by Day 15 all mice in the STAT3-MB + UTMC treated group were still alive compared to only 33% and 14% for STAT3-MB-mut + UTMC and untreated groups, respectively (p<0.05).