ACE inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) decrease the level of ACE and increase the level of ACE2 [14], which may increase the risk of SARS-CoV-2 infection, which may be the reason why more patients with hypertension and coronary heart disease also had lymphopenia, as ACEIs and ARBs are commonly used drugs under these circumstances. The gene discussed is ACE2; the disease is Hypertension.