For example, DeepPheno predicted Lactic acidosis (HP:0003128) as a new phenotype associated with NDUFA1 as well as several related phenotypes such as Decreased liver function (HP:0001410) and Generalized hypotonia (HP:0001290), as well as phenotypes such as Microcephaly (HP:0000252) and Optic atrophy (HP:0000648); all these phenotypes were added as new annotations of NDUFA1 by August 2020. Here, NDUFA1 is linked to Leber hereditary optic neuropathy.