TP53 and neoplasm: For example, Group 4 cell lines show the slowest growth in vitro (supplementary material, Figure S2A: CHLA‐01/01R‐MED), although Group 4 MB is characterized by high metastasis rates and intermediate to poor prognosis concordant with high tumour aggressiveness compared with the less aggressive p53 wild‐type SHH subtype (ONS76).