Besides, the pro-angiogenic factors described in this review differ in terms of their clinical significance and application; in GC patients, the expression of VEGFR-2, CXCR7, EGF, VEGF, IL-8, miRNAs (such as miR-218, miR-135b, miR-495, or miR-130a), or TAMs proliferation seem to be associated with the survival rates, thus, they might act as potential prognostic factors of GC. The gene discussed is ACKR3; the disease is gastric cancer.