HMGB1 and gastric cancer: Angiogenesis is also regulated and stimulated by a vast number of interleukins and their receptors among which IL-1α, IL-8 (via high-mobility group box-1 (HMGB1) contribution), IL-17 (through STAT3 pathway), or soluble interleukin-2 receptor (sIL-2R) are considered to be of the highest importance regarding GC patients; except for neovascularization, IL-1α is involved in liver metastasis of GC [134–137].