Subsequently, it was found that 5‐LO is strongly upregulated in AML1/ETO‐positive AML and that loss of 5‐LO expression impaired cellular dysregulation caused by oncogenic fusion proteins (RUNX1‐ETO9a, MLL‐AF9, and PML‐RARα).17 This evidence concerns the gene RUNX1 and acute myeloid leukemia.