IFN‐λ4 has been studied as an antiviral cytokine1, 2, 3, 4, 5, 6, 7; however, the genetic association of the dinucleotide polymorphism rs368234815, which is responsible for IFN‐λ4 expression, extends beyond viral infections, including several inflammatory disorders,15, 16, 17, 18, 19, 20, 21, 22 and even parasitic infections27 and cancer.28, 29, 30. This evidence concerns the gene IFNL4 and viral infectious disease.