Similarly, while we also implicate CD4+ TEMRA cells in the hyperacute immune response following stroke, further studies in larger patient cohorts are essential to determine their functional consequence and temporality, particularly in the context of long‐term cognitive decline, as increased CD8+ TEMRA cells in circulation have been recently identified as an immunophenotype in patients with mild cognitive impairment or Alzheimer’s disease [78]. This evidence concerns the gene CD8A and early-onset autosomal dominant Alzheimer disease.