The kinases with the highest survival scores have been well described in the literature as predictive and prognostic biomarkers in multiple cancers, notably PGK1, PLK1, and AURKA. 60,64,65 Less-studied kinases such as ALPK3 (Tdark) (Figure S1D) and SPEG (Tbio) also were shown to correlate with survival in six cancer cohorts (Table S6). The gene discussed is SPEG; the disease is cancer.