The kinases with the highest survival scores have been well described in the literature as predictive and prognostic biomarkers in multiple cancers, notably PGK1, PLK1, and AURKA. 60,64,65 Less-studied kinases such as ALPK3 (Tdark) (Figure S1D) and SPEG (Tbio) also were shown to correlate with survival in six cancer cohorts (Table S6). This evidence concerns the gene PLK1 and cancer.