,55,56 Eight understudied kinases were found to have hotspot mutations in at least one cancer (CDC42BPA, DYRK1B, DYRK4, LMTK3, MAPK15, NEK7, TSSK1B, and TTBK1), with DYRK4, LMTK3, MAPK15, and NEK7 all having significant hotspot mutations in STAD. The gene discussed is DYRK1B; the disease is cancer.