CHEK2 and cancer: Literature and other studies confirm that this kinase, a member of the CaMK family, may play a role in promoting metastasis in lung and colorectal cancers via induction by the transcription factor NF-kappaB.61, 62, 63 CaMK members CHEK2, TRIB2, STK17A, and STK17B are also shown to correlate with TNM staging, further highlighting the potential clinical use for CaMKs as novel cancer targets (Table S7).