,55,56 Eight understudied kinases were found to have hotspot mutations in at least one cancer (CDC42BPA, DYRK1B, DYRK4, LMTK3, MAPK15, NEK7, TSSK1B, and TTBK1), with DYRK4, LMTK3, MAPK15, and NEK7 all having significant hotspot mutations in STAD. This evidence concerns the gene DYRK4 and gastric adenocarcinoma.