IL6 and leukemia: GSEA comparisons in the mouse showed that activation of inflammation-associated pathways TNF-α via NF-κB signaling, IFN-γ, inflammatory response, and interleukin-6 (IL-6)/JAK/STAT3 signaling were significantly elevated in leukemia samples relative to non-leukemic LK populations (the expression data of WT and Csf3r-d715 were combined and compared with the combined data of the eight tertiary transplant recipients; Figure 4A).