CFTR and infection: Pseudomonas aeruginosa (PsA) colonization and infection are risk factors for the development of CLAD;3 however, the role of PsA on lung transplant outcomes in patients with CF is less clear.4, 5, 6, 7 Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations may lead to distinct immune responses in CF lung transplant recipients,8 especially when coupled with the unique airway microbiome that CF patients harbor.