The high heterogeneity in terms of techniques and HCC-CCA classification in these studies needs to be underlined.[25], [26], [27], [28] Genomic analysis also suggests an impact of viral hepatitis (HCV and HBV) on the genetic landscape of cHCC-CCA that seems closer to HCC than iCCA in terms of genomic profiles and prevalence of TERT promoter mutations.24 This evidence concerns the gene TERT and cholangiocarcinoma.