BAP1 and hepatocellular carcinoma: ,83 A subset of HCC with fibrolamellar-like features has been shown to occur in non-cirrhotic livers, but in older patients, and was characterised by both BAP1 alterations and an aberrant activation of the protein kinase A pathway due to a chromosome gain of PRKACA combined with a loss of PRKAR2A (the inhibitory regulatory subunit of protein kinase A).84