TP53 and hepatocellular carcinoma: Similar to the genomic alterations observed in HCC, TP53, TERT promoter, AXIN1, KMT2D, ARID1A were the most common mutations in cHCC-CCAs; the frequency of TERT promoter mutations (23%) was lower than in HCCs (40–60%) but higher than in iCCAs (0–8%).