Rarely, obstructive jaundice, gynecomastia in males, encephalopathy, ascites, acute liver failure, recurrent thrombophlebitis, anaemia, hypoglycaemia or Budd-Chiari syndrome can reveal FLC.[90], [91], [92] Differential diagnosis consists of primary liver tumours with fibrosis, such as some subtypes of HCC (especially BAP1 mutated HCC), CCA or focal nodular hyperplasia. This evidence concerns the gene BAP1 and hepatocellular carcinoma.