TERT promoter, TP53, ARID1A and ARID2 mutations are more frequent in cHCC-CCA; PBRM1, BAP1, KRAS, IDH1 and FGFR2 mutations in iCCA; and CTNNB1 mutations in HCC (Fig. 1). The gene discussed is TERT; the disease is cholangiocarcinoma.