Rarely, obstructive jaundice, gynecomastia in males, encephalopathy, ascites, acute liver failure, recurrent thrombophlebitis, anaemia, hypoglycaemia or Budd-Chiari syndrome can reveal FLC.[90], [91], [92] Differential diagnosis consists of primary liver tumours with fibrosis, such as some subtypes of HCC (especially BAP1 mutated HCC), CCA or focal nodular hyperplasia. The gene discussed is BAP1; the disease is cholangiocarcinoma.