CD4 and cryptococcosis: Conversely, early diagnosis during the asymptomatic phase of illness is associated with lower mortality [26,27], and has formed the basis for cryptococcal antigen (CrAg) screening of HIV-positive patients at highest risk of cryptococcosis at time of presentation (PLWH and a CD4 count less than 100 cells/mL) [28] which has been associated with a 28% survival benefit [29].