In Fabry disease, one of the lysosomal storage diseases, GLA mutations defect α‐galactosidase A (α‐GALA) in hydrolyzing the terminal α‐galactosyl moieties from GSLs, and bring about accumulation of Gb3 in cells, particularly in kidneys, heart and skin.61, 62. Here, GLA is linked to lysosomal storage disease.