APC and head and neck squamous cell carcinoma: Among these targets were adenomatous polyposis coli (APC), programmed cell death protein 4 (PDCD4) and TGF beta receptor 3 (TGFBR3), thus concluding that over-expression of these miRNAs might contribute in the down-regulation of mRNAs that control growth and progression of HNSCC [8].