Regarding the TLR3-rs3775294, the allelic distribution revealed a significant decrease of the C allele in the patient group compared to HC (32.5% vs 51.9%; P = 0.03, OR = 0.57 [0.3-0.9]); in addition, the CC genotype showed a quiet protective effect when PF patients (16%) were compared to HC (30.7%) (P = 0.07). The gene discussed is TLR3; the disease is pemphigus foliaceus.