SPRY4 and metastatic malignant neoplasm in the lymph nodes: Elevated SPRY4-IT1 expression was obviously correlated with advanced distant metastasis (OR = 1.736, 95% CI 1.193~2.525, P = 0.004), lymph node metastasis (OR = 1.982, 95% CI 1.112~3.534, P = 0.020), and tumor size (OR = 2.201, 95% CI 1.696~2.857, P < 0.001) [31].