Further experiments highlighted that SPRY4-IT1 may function as a ceRNA and sponge miRNA and thereby scaffolding target genes in cancers, such as miR-101-3p/EZH2 in cholangiocarcinoma [12], miR-101-3p/AMPK axis in gastric cancer [10], and miR-6882-3p/TCF7L2 in breast cancer cell stemness [9]. Here, TCF7L2 is linked to breast carcinoma.