Yu et al. [28] reported that SPRY4-IT1 has interaction with EERα, and SPRY4-IT1 siRNA transfection HepG2 cells significantly inhibited mRNA and protein expression levels of ERRαin in HCC cell lines, thus influencing cell proliferation, colony formation, cell invasion, and migration [29]. The gene discussed is HAUS3; the disease is hepatocellular carcinoma.