Recent studies have shown that long noncoding RNA SPRY4-IT1 has dysregulated expressions in a variety of tumors, including hepatocellular carcinoma [8], breast cancer [9], gastric cancer [10], cervical cancer [11], cholangiocarcinoma [12], pancreatic carcinoma [13], osteosarcoma [14], and colorectal cancer [15]. Here, SPRY4 is linked to cholangiocarcinoma.