In addition, the pooled effects indicate that high SPRY4-IT1 expression is significantly correlated with LNM (OR = 1.982, 95% CI 1.112~3.534, P = 0.020), DM (OR = 1.736, 95% CI 1.193~2.525, P = 0.004), and tumor size (OR = 2.201, 95% CI 1.696~2.857, P < 0.001). The gene discussed is SPRY4; the disease is neoplasm.