Except direct liver injury and subsequent development and progression of liver fibrosis, several hepatokines (e.g., fetuin A and B, selenoprotein P, fibroblast growth factor 21 (FGF12), leukocyte cell-derived chemotaxin 2 (LECT2), and hepassocin (HPS)) are produced. The gene discussed is LECT2; the disease is Hepatic fibrosis.