In obesity, adipose tissue inflammation leads to increased secretion of proinflammatory cytokines (e.g., tumor necrosis factor alfa (TNF-α) and interleukin 6 (IL-6)) and adipokines (e.g., leptin, adiponectin, resistin, and irisin). Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.