Early and correct diagnosis of PDCD and early therapeutic intervention with alternate energy sources (eg, ketogenic diet [KD]13, 14), activators of residual PDC activity (eg, dichloroacetate15 or phenylbutyrate16, 17, 18, 19), and/or thiamine supplementation (50‐2000 mg per day2, 20) could lead to improved developmental and cognitive outcome, quality of life, and survival for infants with primary‐specific PDCD.21, 22, 23. The gene discussed is PDC; the disease is pre-descemet corneal dystrophy.