Since CD82 is located through the cell membrane and most of its functions resorted to the tetraspanin-enriched membrane microdomains (TEM) [15], we focused on the proteolytic modification to unveil the function of CD82 on posttranslational regulation of E-cadherin, which may improve our understanding of the metastatic suppressor role of CD82 and get much more details on the metastasis progress of prostate cancer. This evidence concerns the gene CDH1 and prostate carcinoma.