IL13Ra2-CAR.CD28.ζ T cell proliferation resulted in the production of IFN-γ and TNF-α as well as facilitated phenotypically proinflammatory glioma microenvironment by triggering elevated levels CD4+ and CD8+ T cells and CD8α+ DCs as well as a reduction in Ly6G+ MDSC levels [102]. Here, TNF is linked to central nervous system cancer.